Using low-rank tensor formats to enable computations of cancer progression models in large state spaces

Simon Pfahler1, Peter Georg1, Y. Linda Hu2, Stefan Vocht2, Rudolf Schill2,3, Andreas Lösch2, Kevin Rupp2,3, Stefan Hansch2, Maren Klever4, Lars Grasedyck4, Rainer Spang2, Tilo Wettig1

1 Department of Physics, University of Regensburg
2 Department of Informatics and Data Science, University of Regensburg
3 Department of Biosystems Science and Engineering, ETH Zürich
4 Institute for Geometry and Applied Mathematics, RWTH Aachen University

Correspondence: simon.pfahler@ur.de

Poster

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Code availability

pRC: C++ library for efficient calculations in the Tensor Train format, open source

cMHN: C++ library to work with Mutual Hazard Networks in the Tensor Train format, soon to be open source

Funding

This work is supported by the German Research Foundation (DFG) through the project "Tensorapproximationsmethoden zur Modellierung von Tumorprogression".

Simulation results

The data used to plot the KL-divergences and runtimes can be accessed here:
Runtime plot:

Accuracy plot: